There was a significant improvement in lead acetate induced the hepatic, renal and splenic histopathological changes by the administration of vitamins c and e as compared with dmsa treated rats. Effect of curcumin and curcumin nanoparticles against lead. Request pdf luteolin protects against lead acetateinduced nephrotoxicity through antioxidant, antiinflammatory, antiapoptotic, and nrf2ho1 signaling pathways lead pb is one of the most. Hepatoprotective effect of curcuma longa against lead. The protective effects of dmsa and some vitamins against. Protective effects of piperine on lead acetate inducednephrotoxicity. Pdf nephroprotective effect of low viscosity sodium.
Lead acetate induced kidney damage was well manifested by significant increase in renal parameters like urea, uric acid creatinine and. Protective effect of curcumin on lead acetateinduced. The current study was carried out to evaluate the antioxidant and anticaspase 3 activity of chitosanpinus merkusii nanoparticle in against lead acetate induced nephrotoxicity in rats. Nsrf an herbal formulation developed for improving renal functionson heavy metal lead acetate induced nephrotoxicity in wistar albino rats.
Erythrophagocytosis of leadexposed erythrocytes by renal. The current study was carried out to evaluate the antioxidant and anticaspase 3 activity of chitosan pinus merkusii nanoparticle in against lead acetate induced nephrotoxicity in rats. Indigofera oblongifolia mitigates leadacetateinduced. The methanol extract was used for experiments in animals. The rats of group i received only deionised water as control while, group ii, iii and iv were given lead. Introduction lead pb is a heavy metal distributed into the environment from natural and anthropogenic sources and. Based on the study, it can be stated that lead induced nephrotoxicity particularly damages thestructure of proximal tubules and the damage is more pronounced with increasing time period. Molecular mechanisms underlying the nephrotoxicity of cisplatin, lead acetate and cyclosporine. Silymarin and dimercaptosuccinic acid ameliorate leadinduced.
Groups be were exposed to 2000 ppm of lead acetate in drinking water for 8 weeks. Ameliorative effect of curcumin against lead acetateinduced. Jan 17, 2020 lead, toxic heavy metal of global concern, induces toxicity in various organs via oxidative stress. This study aimed to investigate the potential effects of berberis vulgaris l. The kidney is among the metabolic organs most susceptible to injury, particularly following exposure to xenobiotics and heavy metals. Lack of reversal of oxidative damage in renal tissues of lead. Lead acetate salt was dissolved in deionised water, while ac was. Lead acetate, nephrotoxicity introduction lead pb is a poisonous metal, which is ubiquitous in both organic tetraethyl lead and inorganic lead acetate, lead chloride forms in environment1 and is emitted from automobile fuels, industrial discharge and paints. We investigated whether paeonol could improve pbinduced inflammation and er stress by the ampk pathway.
Key roles of myc and smad4 hassan askari 1, ehsan raeis abdullahi1, vahdat poortahmasebi2, mohammad foad abazari3, matin asghari 4, solmaz sadeghi5, danya abazari6, reza mahmoudi7, amir savardashtaki 8 and mansour poorebrahim5 1department. Jcprc5 175 influence of aqueous and diethyl ether extracts of pongamia pinnata flowers on lead acetate induced nephrotoxicity anuradha r. Effect of curcumin and curcumin nanoparticles against lead induced. Indigofera oblongifolia mitigates leadacetateinduced kidney damage and apoptosis in a rat model mohamed a dkhil,1,2 mohamed s alkhalifa,1 saleh alquraishy,1 rafat zrieq,3 ahmed esmat abdel moneim2 1department of zoology, college of science, king saud university, riyadh, saudi arabia. Indigofera oblongifolia mitigates lead acetate induced kidney damage and apoptosis in a rat model mohamed a dkhil,1,2 mohamed s alkhalifa,1 saleh alquraishy,1 rafat zrieq,3 ahmed esmat abdel moneim2 1department of zoology, college of science, king saud university, riyadh, saudi arabia. Concomitanttreatment with essential m icronutrient zinc reduces or delays the toxic effects o f lead. In contrast, significant recovery of the histological picture of liver, kidney and spleen in the lead acetate induced hepatotoxicity. In the present study the nephroprotective potential of aqueous and diethyl ether extract of pongamia pinnata flowers were assessed in lead acetate induced nephrotoxic rats. The aim of the present study was to examine the protective effect of curcumin cur and curcumin nanoparticles curnps as antioxidants on the nephrotoxicity induced by lead pb. Frontiers coenzyme q10 activates the antioxidant machinery.
Therefore, the purpose of this study was to explore the protective effect of curcumin. Dosedependent effect of coriander coriandrum sativum l. The period of lead intoxication extended for 3 months followed by either 1 month treatment with garlic and silymarin or 5 days treatment with dmsa. To understand the reversibility of nephrotoxicity induced by lead acetate, male wistar rats were orally exposed to 0. Sujatha kt, srilatha ch, anjaneyulu y, amaravathi p. Lead acetate and curcumin were purchased from sigma. Protective effects of spirulina against hematobiochemical. Therefore this study aims to investigating the effect of pretreatment with osm on cadmium and lead induced nephrotoxicity. The present study was conducted to examine the nephrotoxic effects of heavy metals including lead pb, manganese mn, arsenic as, and cadmium cd in diabetic and nondiabetic wistar rats. The current study was carried out to evaluate the antioxidant and anticaspase 3 activity of chitosanpinus merkusii nanoparticle in against lead acetateinduced nephrotoxicity in. Indigofera oblongifolia mitigates leadacetateinduced kidney damage and apoptosis in a rat model.
Oxidative stress plays a key role in leadinduced nephrotoxicity. Experimental design rats were divided into 6 groups of 12 rats each as follows. The oral administration of water soluble fraction of the diethyl ether. Sodium fluoride induces nephrotoxicity via oxidative. Autophagy blockade and lysosomal membrane permeabilization.
Oxidative stress and apoptotic changes in primary cultures of rat proximal tubular cells exposed to lead. Group e received dmsa and silymarin as groups c and d, respectively. Nephrotoxicity was induced by giving rats lead acetate dissolved in distilled water at dose 50 mgkg body weight day by gastric tube 20. Four experimental groups n 7 were applied as follows. Looking to the pharmacological properties of different varieties of opuntia spp. Lead induced chronic renal failuredefinitionlead pb nephrotoxicity relates to experimental, epidemiologic, and clinical evidence of renal damage and. In the present study we examined the role of erythrocytes in leadinduced nephrotoxicity in vitro in a coculture system as well as in vivo in rats. Ac may be beneficial in chronic lead induced liver and kidney damage.
Efficacy of curcumin on lead induced nephrotoxicity in female. Womens college, sundarakottai, mannargudi, tamilnadu, india. Request pdf lead acetate induced nephrotoxicity in wistar albino rats. It was concluded that spirulina maxima has protective effects on lead acetateinduced damage, and that the effects are associated with the antioxidant effect of spirulina. Chitosan pinus merkusii nanoparticles were identified by particle size analysis psa and scanning electron.
Effect of lead acetate toxicity on experimental male albino rat. Pbac was intraperitoneally injected at a dose of 20 mgkg body weight for 5 days, either alone or. Request pdf luteolin protects against lead acetate induced nephrotoxicity through antioxidant, antiinflammatory, antiapoptotic, and nrf2ho1 signaling pathways lead pb is one of the most. Antioxidant and nephroprotective effects of okra pods extract. Curcumin attenuates leadinduced cerebellar toxicity in rats via chelating activity and inhibition. Morphological study of lead induced nephrotoxicity with. Nephrotoxicity was induced in wistar rats by intraperitoneal administration of lead acetate 8mgkgday for 21 days and oral administration of cadmium chloride 50mgkg for a single day. These properties of solanum anomalum may play a positive role in the defense against oxidative stress induced by lead acetate. Curcumin has been reported to have a strong antioxidant activity. Induction of nephrotoxicity lead acetate pb c 2 h 3 o 2 2 was purchased from sigma for chemicals company cairo. Neuroprotective potential of indigofera oblongifolia leaf methanolic extract against lead acetateinduced neurotoxicity saleh alquraishy 1, mohamed a dkhil 2, shaimaa r ibrahim 3, ahmed e abdel moneim 4 1 department of zoology, college of science, king saud university, riyadh, saudi arabia 2 department of zoology, college of science, king saud university, riyadh, saudi arabia.
In this study, we investigated the protective effects of piperine on lead acetateinduced renal damage in rat kidney tissue. Metalinduced nephrotoxicity to diabetic and nondiabetic. Thus, this study has been designed to investigate the effect of low viscosity sodium alginate lvsa in leadinduced nephrotoxicity. We aimed to explore the potential protective impacts of coenzyme q10 coq10 on lead acetate pbacinduced nephrotoxicity in rats. Animals were exposed to heavy metals for 30 days, pb was injected as lead acetate c4h6o4pb, mn was injected as manganese chloride mncl2, cd was injected as. The aim of the current study was to investigate the protective effect of hydroalcoholic r.
Protective effect of curcumin on lead acetateinduced testicular toxicity in wistar rats in recent years, the use of the antioxidant in reducing heavy metal toxicities has increased worldwide. Pdf influence of aqueous and diethyl ether extracts of. The potency of chitosanpinus merkusii extract nanoparticle. Lead induced hepatorenal damage in male albino rats. Mice were exposed chronically to lead acetate, at a dose of 5 mgkg, alone or in conjunction with b. The present study is aimed to investigate the protective effects of neeri. Lead acetate ingestion induced alteration in redox status as indicated by a decrease in glutathione levels.
Improvement of lead acetateinduced testicular injury and. Thus, in this study, we for the first time reveal the functions and mechanisms of paeonol on pbinduced nephrotoxicity. Dec 26, 2017 thus, this study has been designed to investigate the effect of low viscosity sodium alginate lvsa in lead induced nephrotoxicity. Thereby, in this study, the protective role of curcumin against lead acetate induced toxicity was evaluated. Toxicology letters, 46 1989 153162 153 txl 02127 mechanisms of lead and cadmium nephrotoxicity r. Pdf protective effects of piperine on lead acetate induced. Lack of reversal of oxidative damage in renal tissues of. We evaluated the protective efficacy of lut against pb induced renal injury in male wistar.
The role of the extract as an antioxidant was tested by dpph and frap methods. Effect of lead acetate toxicity on experimental male. Thus, this study has been designed to investigate the effect of low viscosity sodium alginate lvsa in lead induced nephrotoxicity. The potential molecular protective effects of curcumin on lead acetate induced hepatotoxicity and nephrotoxicity have not been explored well. This study was conducted to appraise the protective effect of indigofera oblongifolia leaf extract on lead acetate pbacinduced nephrotoxicity in rats. Autophagy blockade and lysosomal membrane permeabilization contribute to leadinduced nephrotoxicity in primary rat proximal.
To evaluate the effect of different doses of lead acetate 120, 140 and 160 of ld50 on body weight gain, blood picture, plasma protein profile and the function of liver, kidney and thyroid gland. Haematobiochemical alterations induced by lead acetate. Searching pubmed using nephrotoxicity as the search term results in 16,008 related papers, with the earliest paper cited describing the nephrotoxicity induced by cystine. Efficacy of astragalin on lead acetate induced nephrotoxicity in male albino rats. Protective effect of spirulina on lead induced deleterious. Research open access protective effects of spirulina. The aim of the present study is to clarify the possible corrective role of curcumin on the nephrotoxicity induced by lead acetate. Nephroprotective effect of low viscosity sodium alginate on. Mar 19, 2018 this study measured the effects of vitamin d vd supplementation on the underlying molecular pathways involved in renal and testicular damage induced by lead pb toxicity. Lead pb toxicity remains a significant public health problem because of its global pervasiveness and its adverse effects on the renal system. The role of antioxidant activity of chitosanpinus merkusii. Research, report by environmental health perspectives. In conclusion, these data shedding light on new approaches for treatment of nafinduced nephrotoxicity. Lead acetate induced nephrotoxicity in wistar albino rats.
The aim of this study was to evaluate the antioxidant activity of chitosanpinus merkusii extract nanoparticle on lead acetate induced toxicity in rat pancreas. It induces nephrotoxicity with significant alterations in renal structure and function. Rats were exposed to lead acetate in the drinking water 500 mg pbl with or without quercetin coadministration 25 and 50 mg qukg intragastrically once daily. Lead is one of the heavy metals with oxidative stress that causes toxicity in human and animals.
The current study was aimed at exploring the protective efficacy of spirulina against the hematobiochemical alterations and nephrotoxicity induced by. Luteolin lut a flavonoid present in various plant products is well known for exhibiting numerous pharmacological properties. Nephrotoxicity, biochemical alterations, lead, allium sativum, vitamin c, rats. Original article nephroprotective effect of low viscosity. Wistar rats were divided into normal, lead exposure groups, lead plus quercetin groups and quercetin groups. Lead acetate mediated toxicity resulted in a significant decrease in epididymal sperm reserve, testicular sperm count, percent sperm motility and percent sperm viability. Neuroprotective potential of indigofera oblongifolia leaf. Thirtytwo male albino rats were allocated equally into four groups and orally administered with corn oil as a vehicle cont. Lead administration 250, 500, and 2000 ppm, as lead acetate in drinking water during fetal development from 15 to 20 days of gestation, in normal and irondeficient pregnant rats, revealed dosedependent increases in the lead content of maternal blood that was more marked in irondeficient animals. Role of ampk pathway in leadinduced endoplasmic reticulum. Lead acetate was administered at dose rate of 500 ppm in feed, p. Sodium fluoride induces nephrotoxicity via oxidative stressregulated mitochondrial sirt3.
Effect of lead toxicity on cytogenisity, biochemical constituents and tissue residue with protective role of activated charcoal and casein in male rats. Oxidative stress plays a key role in lead induced nephrotoxicity. Curcumin attenuates leadinduced cerebellar toxicity in. Historical perspective of nephrotoxicity toxicological. Background the lead is a xenobiotic, persistent toxic 1,2, as other xenobiotics induces to different health risks since the fetal stage until senescence. The current study was carried out to evaluate the antioxidant and anticaspase 3 activity of chitosan pinus merkusii nanoparticle in against lead acetateinduced nephrotoxicity in rats. We evaluated the protective efficacy of lut against pbinduced. Lead has been associated with various forms of cancer, nephrotoxicity, central nervous system effects and cardiovascular diseases in human. Indigofera oblongifolia mitigates leadacetateinduced kidney. Goyer department of pathology, university of western ontario, london, ontario, n6a 5c1 canada summary exposure to lead results in accumulation in proximal renal tubular lining cells in the form of mor phologically discernible inclusion bodies which are lead protein complexes. Medical and environmental applications of activated charcoal. Pdf efficacy of astragalin on lead acetate induced.
Mechanisms of lead and cadmium nephrotoxicity sciencedirect. In this study, we investigated the protective effects of piperine on lead acetate induced renal damage in rat kidney tissue. Lead pb is one of the most common heavy metal pollutants affecting living organisms. Luteolin protects against lead acetateinduced nephrotoxicity. In the present study we examined the role of erythrocytes in lead induced nephrotoxicity in vitro in a coculture system as well as in vivo in rats. In contrast, significant recovery of the histological picture of liver, kidney and spleen in the lead acetateinduced hepatotoxicity. This study was conducted to compare the curative role of garlic combined with silymarin versus dimercaptosuccinic acid dmsa in decreasing lead induced nephrotoxicity in adult male albino rats. Erythrophagocytosis of lead exposed erythrocytes by renal tubular cells. The aim of this study was to evaluate the antioxidant activity of chitosan pinus merkusii extract nanoparticle on lead acetateinduced toxicity in rat pancreas. Protective effects of piperine on lead acetate inducednephrotoxicity in rats. The effect of pb was evaluated and accordingly the treatments on blood lead levels blls, renal system, and genotoxic effects were calculated using comet assay. The full text of this article hosted at is unavailable due to technical difficulties. Efficacy of curcumin on lead induced nephrotoxicity in. On the basis of available evidence, we hypothesized that lead induced ps externalization in erythrocytes promotes erythrophagocytosis by renal tubular cells, contributing to lead associated kidney.
Vitamin d alleviates lead induced renal and testicular. Silymarin and dimercaptosuccinic acid ameliorate lead. An experiment was conducted to study the haematobiochemical alterations induced by lead acetate toxicity in 48 wistar rats of either sex, divided uniformly into four different groups. Nephroprotective effect of low viscosity sodium alginate. The present study was carried out to evaluate the toxicopathological manifestation of lead acetate toxicity in broiler chickens with protective effect of opuntia elatior fruit juice and extract of withania somnifera. A pathological, immunohistochemical and ultrasructural studies lead is a long known. Lead acetate, heavy metals, neeri nsrf, vitamin e, oxidative stress, nephrotoxicity. Ameliorating effect of lcysteine on lead acetateinduced.
Key roles of myc and smad4 hassan askari 1, ehsan raeis abdullahi1, vahdat poortahmasebi2, mohammad foad abazari3, matin asghari 4, solmaz sadeghi5, danya abazari6, reza. Antioxidant and nephroprotective effects of okra pods. On the basis of available evidence, we hypothesized that leadinduced ps externalization in erythrocytes promotes erythrophagocytosis by renal tubular cells, contributing to leadassociated kidney. Reports of nephrotoxicity research continue to increase each decade with only 80 articles before 1970 to over 5300 papers between 2010 and 2018. Pdf objectives in this study, we investigated the protective effects of piperine on lead acetateinduced renal damage in rat kidney. However, paeonolmediated protection against pbinduced kidney injury has not been identified now.
The blls were significantly increased following the exposition of lead acetate. Health, general environmental issues erythrocytes physiological aspects kidney diseases risk factors lead health aspects lead metal red blood cells. Leadinduced fetal nephrotoxicity in irondeficient rats. Toxicopathological studies on experimentally induced lead. Protective effect of curcumin on lead acetate induced testicular toxicity in wistar rats in recent years, the use of the antioxidant in reducing heavy metal toxicities has increased worldwide.
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